BRAF Mutation in Colorectal Cancer: An Update
2015-9-6 · BRAF and Mutated BRAF. The serine/threonine protein kinase BRAF is an important player in the epidermal growth factor receptor (EGFR)-mediated mitogen-activated protein kinase (MAPK) pathway, where it is activated by the RAS small GTPase. 12 The strength of BRAF, and also its extension to other RAF isoforms (ARAF and CRAF), is to not only activate the MAPK pathway that profoundly …
